BASIC UNDERSTANDING OF THE LUTEAL SUPPORT (LPS) IN ART TREATMENT CYCLES (Summary of the program)
Capsule: Ovarian stimulation results in supraphysiological steroid concentrations along with low LH levels during the luteal phase, approximately 8-9 days after hCG administration. This results in decreased corpus luteum production of estrogen and progesterone, which is associated with decreased probability of successful implantation and ongoing pregnancy.The triggering of the final stages of ovulation using either hCG (5,000-10,00IU) or GnRH-a induce specific, yet different adverse consequences on the luteal phase that call for corrective measures. The program developed below was built to raise the controversies on the subject, striving to reach a consensus regarding lutal support in ART cycles.
Session 1
Chairpersons: Dominique De Ziegler, France; Zeev Shoham, Israel
- Is there a dose-effect relationship in the endometrial effects of progesterone ?
- Dominique De Ziegler, France
- Why do we need additional progesterone when endogenous levels are so high?
- Pedro Barri, Spain
Panel discussion
- Should LPS be adjusted to the COS regime?
- Milton Leong, Hong Kong
- Luteal phase support in ovulation induction cycles
- Salim Daya, Canada
- Which formulation should we use?
- Roy Homburg, Israel
- Which is the optimal duration of LPS in pregnancy: Science vs. clinical practice
- Zeev Shoham, Israel
- Is there a place for IM progesterone supplementation ?
- Sherman Silber, USA
Session 2
How do we choose the treatment?
Chairpersons:
Dominique De Ziegler, France;
Zeev Shoham, Israel;
Sedat Kadanalı, Turkey
- Luteal support in ART treatment cycles: Is there a place for new/old formulation?
- Salim Daya, Canada
- Latest results from IVF worldwide survey
- Zeev Shoham, Israel
- Luteal phase after GnRH agonist ovulation triggering
- Seang Lin Tan, Canada
Panel discussion
- Is there a risk involved in additional or high dose progesterone during the luteal phase or early pregnancy?
- Dominique De Ziegler, France
- Is there a role for gonadotropin releasing hormone (GnRH)-agonists as a luteal supplement in GnRH- agonist and antagonist stimulated cycles?
- Pedro Barri, Spain
- Active management of the luteal phase
- Baris Ata, Turkey
- Should hCG be added to all supplemented protocols?
- Gedis Grudzinskas, UK
- Is there a need for additional estrogen supplementation?
- Ariel Weissman, Israel